ProGREsS
Research type
Research Study
Full title
Personalised Genetic Risk Estimates for Cancer Screening & Prevention
IRAS ID
213897
Contact name
J Krell
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This is a 2-part study and combines a questionnaire study within the general population with a personalised cancer risk assessment study in a smaller group of women.
Part 1 involves the completion of an online questionnaire by the local population and the aim is to evaluate the awareness and understanding of genetic testing within this population.
Part 2 will be done in GP practices within the local area. Women will be asked to provide blood and saliva samples and complete a questionnaire. These data will be analysed to produce an individualised breast and ovarian cancer risk score. Patients will be advised of their risk score and prevention strategies and the study will look in detail at changes in the epigenome with use of the oral contraceptive pill. The aim of part 2 is to help determine whether risk assessment calculations can help patients to make informed decisions about disease prevention behaviours. The study will also analyse whether the use of family history and epidemiological factors can be used to streamline cancer genetic testing in the primary care setting
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
18/EM/0070
Date of REC Opinion
4 Jun 2018
REC opinion
Further Information Favourable Opinion