Prognostic Biomarkers in Epilepsy (ELMO) Study

• Research type

  Research Study

• Full title

  Epileptic Encephalopathies Longitudinal Multicentre Omics (ELMO) Study. Workpackage 2 of "Development and Epilepsy - Strategies for Innovative Research to Improve Diagnosis, Prevention and Treatment in Children with Difficult to Treat Epilepsy (DESIRE)" FP7 Pathomechanisms in Epilepsy Programme.

• IRAS ID

  136623

• Contact name

  Deb Pal

• Contact email

  deb.pal@kcl.ac.uk

• Sponsor organisation

  King's College London

• Research summary

  This is part of a European consortium study to discover biomarkers that predict the course of epilepsy and response to treatment in individuals followed from the time of diagnosis. 100 individuals will be followed up and undergo serial clinical monitoring, EEG analysis, and collection of blood samples. We will examine patterns of DNA sequence, gene expression, gene methylation, autoantibody titers, imaging and electroclinical parameters, for prognostic value and perform time-series analyses to describe changes. After univariate analyses, we will identify a biomarker set associated with adverse outcomes.

• REC name

  London - Central Research Ethics Committee

• REC reference

  14/LO/1022

• Date of REC Opinion

  24 Jul 2014

• REC opinion

  Further Information Favourable Opinion