Procoagulant phospholipids in arterial thrombosis
Research type
Research Study
Full title
A pilot, exploratory study to investigate procoagulant phospholipids in arterial thrombosis
IRAS ID
243701
Contact name
Majd Protty
Contact email
Sponsor organisation
Cardiff and Vale University Health Board
Duration of Study in the UK
3 years, 3 months, 0 days
Research summary
Cardiovascular (heart) disease is the number one cause of death in the UK. Patients with heart disease who experience a heart attack are at a higher risk of suffering another heart attack, stroke or death. Heart attacks happen as a result of blockages in heart arteries. These blockages are caused by inflammation (a reaction to a damaging irritant) and lead to activation of blood cells such as white cells (responsible for wound healing) and platelets (responsible for blood clotting) which in turn lead to abnormal clotting and blockages in arteries.
Blood clotting happens through interactions of blood proteins with particular fats (phospholipids) that are present on the surface of blood cells and are linked to inflammation. Their potential role in driving abnormal clotting events in heart attacks is unknown. If identified, it may serve as a potential new treatment. This is important since one in ten patients who experience a heart attack remain at risk of developing another heart attack, or a stroke, despite current treatment.
Here, I will characterize the phospholipid profile generated by blood cells and components in patients with heart disease, with the aim of identifying the drivers of clotting in these patients, and new treatment targets.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
18/YH/0502
Date of REC Opinion
17 Jan 2019
REC opinion
Further Information Favourable Opinion