PROCALCITONIN-HF

• Research type

  Research Study

• Full title

  Studies of the effects of a one week course of either ciprofloxacin or metronidazole on plasma concentration of procalcitonin in patients with heart failure and elevated plasma procalcitonin concentrations.

• IRAS ID

  90536

• Contact name

  John Cleland

• Sponsor organisation

  Hull and East Yorkshire Hospitals NHS Trust.

• Eudract number

  2011-004745-40

• ISRCTN Number

  n/a

• Clinicaltrials.gov Identifier

  n/a

• Research summary

  Procalcitonin (PCT) is a marker of infection. However, plasma concentrations of procalcitonin are also increased in patients with heart failure and indicate a poor prognosis. Other markers of inflammation are also often elevated in patients with heart failure and this has been attributed to translocation of bacteria or endotoxins from the gasto-intestinal tract. We intend to use randomly assigned, one-week courses of azithromycin or metronidazole as therapeutic probes to investigate potential mechanisms leading to increased PCT in heart failure. This may help determine the mechanism for elevated PCT in heart failure and whether it is a possible therapeutic target.

• REC name

  East Midlands - Leicester Central Research Ethics Committee

• REC reference

  12/EM/0019

• Date of REC Opinion

  14 Feb 2012

• REC opinion

  Further Information Favourable Opinion