Probiotics for the prevention of AAD and CDAD

• Research type

  Research Study

• Full title

  Probiotics for the prevention of Antibiotics associated diarrhoea and Clostridium difficile associated diarrhoea

• Contact name

  Neil Haslam

• Sponsor organisation

  Wrightington, Wigan and Leigh NHS Trust

• ISRCTN Number

  N/A

• Research summary

  Antibiotic associated diarrhoea (AAD) and Clostridium difficle associated diarrhoea (CDAD) are serious health care acquired infections occuring after antibiotic use. Probiotics have been proposed as a prevention and some studies have shown benefits. We want to establish whether giving the probitioc VSL#3 to a wide range of patients on antibiotics prevents the development of AAD and CDAD. 450 Patients in 4 hospitals will be recruited to receive either VSL#3 or a placebo. Outcome will be measured by how many develop AAD and CDAD, length of hospital stay and 30 day mortality.

• REC name

  West Midlands - Black Country Research Ethics Committee

• REC reference

  08/H1204/147

• Date of REC Opinion

  28 Apr 2009

• REC opinion

  Further Information Favourable Opinion