PrOAF-HF

• Research type

  Research Study

• Full title

  PrOAF-HF: Predicting Outcomes in Atrial Fibrillation and Heart Failure

• IRAS ID

  318987

• Contact name

  Mark O'Neill

• Contact email

  mark.o'neill@kcl.ac.uk

• Sponsor organisation

  Guy's & St Thomas' NHS Foundation Trust

• Duration of Study in the UK

  2 years, 5 months, 30 days

• Research summary

  Atrial fibrillation (AF) is a common condition causing an irregular heart beat and heart failure (HF) is a condition which affects the ability of the heart to pump blood around the body.

  The two conditions can exist together and there are two treatment options: rate control, where AF is not treated but drugs are used to slow the heart rate, or rhythm control, where AF is treated to return the heartbeat back to a normal regular rhythm. Rate control is the first-line treatment, but some patients do much better under rhythm control.

  Identifying patients that will do best under rhythm control remains a significant clinical challenge. Potential responders to rhythm control can be identified by their disease history though this is often unknown, or their response to treatment, which can only be seen once the therapy has been delivered. We aim to address these challenges by developing computer models to understand patient history and predict how patients may respond to treatment.

  In the future this may be used to ensure that individual patients receive the best treatment possible. Computer models will be used to answer three questions in studies. Models will be used to predict: 1) if AF led to HF, or HF led to AF in AF-HF patients where the disease which occurred first is unknown; 2) response to rhythm control therapy in AF-HF patients and 3) when rate or rhythm control is best, in specific AF-HF patients.

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  24/NW/0056

• Date of REC Opinion

  9 Apr 2024

• REC opinion

  Further Information Favourable Opinion