Prevalence of sleep disturbance in HIV adult population, Version 1
Research type
Research Study
Full title
Prevalence of sleep disturbance in a HIV adult population: a comprehensive mapping of sleep disturbance in HIV patients.
IRAS ID
177492
Contact name
Suveer Singh
Contact email
Sponsor organisation
Chelsea and Westminster Hospital NHS Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Recent prevalence studies in US and French centers suggest that sleep disturbance is self-reported in at least 36% of the HIV+ patients questioned. Insomnia is present in 46.1-47% of the patients questioned (Crum-Cianflone, N. et al, 2012; Allavena, C. et al, 2012).
The causes of this sleep disturbance may be due to the infection itself, its complications,confounders (e.g.medication),or a combination.The impact on disease outcomes are poorly studied.
At the moment, there are no prevalence reports of sleep disturbance in HIV population in the United Kingdom. Our aim is to determine the prevalence of sleep disturbance and possible contributors, in a large sample of HIV positive patients, attending outpatients at Chelsea and Westminster Hospital NHS Trust.
We will conduct a cross section, observational study.
We will use an initial survey to screen the presence of sleep disturbance, followed by an extensive self- reported sleep assessment using 6 validated sleep questionnaires , to map the sleep disturbance and symptoms referred by patients. All patients attending outpatients clinics will be invited to participate in the study. Informed participants' consent will be required.
Factors potentially associated will be collected from medical records, including demographics, time since diagnosis, therapeutic and self-reported substance use and other medical conditions (such as neuropathy), CD4 cell counts and viral load.
We aim to collect our sample in the HIV outpatient setting during a year. We expect to achieve the desired sample size of 356 participants.
In future, such detailed mapping of the sleep disturbance may enable the development of a better diagnostic pathway, creating a tool to distinguish types of sleep disturbance. This can allow tailored therapeutic approaches more efficiently, improving life quality and disease progression, in HIV+ patients, but also as a model for sleep diagnosis in other chronic conditions.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0120
Date of REC Opinion
18 Mar 2016
REC opinion
Unfavourable Opinion