Pressure-flow velocity of coronary stenoses pre and post TAVI
Research type
Research Study
Full title
Exploring the pressure-flow velocity characteristics of coronary stenoses pre and post Transcutaneous Aortic Valve Insertion (TAVI)
IRAS ID
155543
Contact name
Sayan Sen
Contact email
Sponsor organisation
AHSC Joint Research Office, Imperial College London
Research summary
The aortic valve controls the amount of blood that can be pumped out of the heart. In aortic stenosis this valve becomes narrowed and limits the amount of blood that can be pumped around the body. This can cause chest pain and shortness of breath. About 1 in every 2 patients with aortic stenosis also have narrowings of the arteries that supply blood to the heart. These arterial narrowings can also cause chest pain and shortness of breath. Determining if the artery or the valve is the cause of the patient’s symptoms is currently not possible; as a result both are treated and this increases the risk of complications, such as bleeding, heart attacks and stroke.
This study aims to use special sensor tipped wires that can measure how blood flows in a coronary artery to try and determine if the severity of the narrowings in the heart arteries can be assessed independently from the valve. This may allow us to identify if the patients arteries or valve is the cause of chest pain/ shortness of breath and therefore only treat the responsible condition, thereby reducing the risk of complication.REC name
South Central - Oxford B Research Ethics Committee
REC reference
14/SC/1103
Date of REC Opinion
14 Jul 2014
REC opinion
Favourable Opinion