Preoperative Assessment of Invasive Lobular Carcinoma of the Breast
Research type
Research Study
Full title
Preoperative Assessment of Invasive Lobular Carcinoma of the Breast comparing Digital Breast Tomosynthesis with C-view, and Magnetic Resonance Imaging
IRAS ID
234609
Contact name
Paul Lewis
Contact email
Sponsor organisation
Institute of Life Science, Swansea University, Singleton Park, Swansea
Duration of Study in the UK
0 years, 9 months, 18 days
Research summary
Invasive lobular carcinoma (ILC) of the breast is the second most common cancer. It accounts for 5-15% of all breast tumours. ILC is more mammographically and sonographically occult than other breast tumours owing in part to an infiltrative pattern of invasion. Tumour size and extent is often underestimated by mammography such that magnetic resonance imaging (MRI) of the breast is requested preoperatively in addition to standard imaging to exclude multifocality, assess the tumour size and extent, and exclude bilaterality. MRI however has been shown to increase re-excision/ mastectomy rates by up to 60%. Development of Digital Breast Tomosynthesis (DBT) from the digital platform has enhanced imaging of the breast by producing a series of thin slice images which reduce the effect of superimposition. This has been found to improve lesion visibility and assessment, and in addition has been shown to demonstrate architectural distortion more clearly than other modalities. This is relevant as ILC often appears as an architectural distortion on imaging. In addition generation of synthetic 2D images (s2D) from the DBT 3D dataset has been shown to improve cancer detection rate in studies in screening. The primary aim of the study is to compare the preoperative size of ILC comparing DBT/s2D, sonography and MRI breast with final surgical pathology size as the comparator. There will be no additional interventions or investigations on patients. The research is purely an assessment of existing data.
REC name
HSC REC B
REC reference
18/NI/0025
Date of REC Opinion
7 Feb 2018
REC opinion
Further Information Favourable Opinion