Pregnancy dating test - The fall of hPL in urine over time
Research type
Research Study
Full title
Pregnancy dating test – The fall of hPL over time
IRAS ID
198143
Contact name
Spyros Bakalis
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Trust
Duration of Study in the UK
0 years, 2 months, 17 days
Research summary
Our goal is to develop a urine test that measures the rise of human placental lactogen (hPL) to identify clinically useful pregnancy dates to support the delivery of safe, high quality care to pregnant women. An earlier study showed for the first time that it was possible to measure hPL in urine and use the concentration to date the pregnancy.
We know from serum studies that the half-life of hPL is ninety minutes and that it is excreted unchanged in urine; consequently, there is real potential to use the fall in hormone levels in urine to monitor the outcome of natural and artificial abortions or placental health in pregnancy.
This study will focus on the fall of hPL following delivery by Caesarean section when women have a urinary catheter in place and sampling urine is simple to achieve.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
19/YH/0359
Date of REC Opinion
18 Oct 2019
REC opinion
Favourable Opinion