Predictive value of smooth muscle autoantibodies

• Research type

  Research Study

• Full title

  Predictive value of smooth muscle antibodies in determining future risk of autoimmune hepatitis.

• IRAS ID

  155342

• Contact name

  Stephen Holding

• Contact email

  steve.holding@hey.nhs.uk

• Duration of Study in the UK

  1 years, 5 months, 31 days

• Research summary

  Smooth muscle antibodies are associated with autoimmune hepatitis (AIH). However, there are three forms of smooth muscle antibody (SMA), a number of ways of testing for these antibodies, and no data on outcomes for patients with a positive antibody test and normal liver function.
  This research aims to determine the prognosis for these patients by:
  (i) establishing 10+ year outcomes from a large cohort of patients with SMA and normal liver function
  (ii) establishing shorter term outcomes for a smaller group of patients that had SMA tested by a number of methods as part of a method evaluation.
  This study will enable more informed advice and guidance to doctors and patients regarding prognosis and appropriate followup.

• REC name

  North West - Greater Manchester West Research Ethics Committee

• REC reference

  15/NW/0489

• Date of REC Opinion

  8 Jun 2015

• REC opinion

  Favourable Opinion