Predicting response to antidepressants in adolescents
Research type
Research Study
Full title
An exploratory investigation in adolescent depressed patients initiating treatment with fluoxetine, to determine the sensitivity and specificity of the P1vital® PReDicT-AD Test in predicting drug response and non-response
IRAS ID
240465
Contact name
Anthony James
Contact email
Sponsor organisation
Oxford Health Foundation NHS Trust
Clinicaltrials.gov Identifier
18/sc/0470,
Duration of Study in the UK
1 years, 6 months, 30 days
Research summary
Summary of Research
Depression in childhood and adolescence occurs in 1–2% of pre-pubertal children and 3–8% of adolescents, with a lifetime prevalence by age 16 of around 10%. Unfortunately, early onset depression is a serious illness: patients are more impaired socially and functionally; their quality of life is poorer; they have a more negative view of life and self, and they have more lifetime depressive episodes, suicide attempts and suicidal ideation. Early-onset depression can be more severe than later onset. However, only approximately one third of patients recover with the first medication prescribed. The slow clinical onset of antidepressant action means that the detection of response or non-response requires 4-6 weeks of drug treatment.
The P1vital® 'Predicting Response to Depression Treatment' (PReDicT) Test is a set of computer-based cognitive and emotional tasks developed to detect antidepressant response in adults. After 7 days of taking medication, it has been shown to predict response to treatment some 4-6 weeks later. The current study is to see if the PReDicT Test can be modified for use in adolescents- the PReDicT-Adolescent Test (PReDicT-AD Test). The aim is to test how well this test can predict drug response and non-response using data collected approximately 7 days after starting antidepressant treatment in adolescents. With this information we hope to develop for the first time a computer algorithm or formula to predict antidepressant response in this age group.Summary of Results
Unfortunately, recruitment was limited before the COVID pandemic and restrictions made restarting with CAMHS colleagues non-feasible . The study, therefore, had to be stopped. We regret this.REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0470
Date of REC Opinion
19 Feb 2019
REC opinion
Further Information Favourable Opinion