Predicting REsponsE froM Percutaneous valve inTervention (PRE-EMPT)
Research type
Research Study
Full title
Predicting REsponsE froM Percutaneous valve inTervention (PRE-EMPT)
IRAS ID
331495
Contact name
Kush Patel
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
A common type of valve disease called mitral regurgitation (MR) causes significant breathless, several heart diseases and early death. A new treatment is available that has largely benefitted patients who are at high risk for surgery. This treatment is called transcatheter valve repair/replacement (TVR). Thus far, clinical evidence suggests that less than half of patients benefit from TVR. Most either die or remain breathless. We do not yet know who will and who will not benefit from TVR. This study aims to do that by focusing on the blood circulation within the lungs and the right side of the heart.
MR increases the pressures within the lungs. Over time and with increasing severity of MR, the blood vessels in the lungs can undergo an irreversible change such that their blood pressure remains elevated despite treating the MR. In a similar way, the increased blood pressure in the lungs prevents the right side of the heart from working well. And sometimes the right side cannot recover its function despite treating the MR. We believe that such patients, where either the blood pressures in the lungs remains high and/or the right side remains weak, do not gain benefit from TVR.
In order to test this theory, we will carry out a research study at St Bartholomew’s Hospital among patients undergoing TVR for MR. These patients will have heart scans, an assessment of their blood vessels in their lungs, blood tests and questionnaires both before and at 6 months after the TVR. We will compare the results among patients who feel better with TVR to those who do not feel better. In doing so we can understand what characteristics define the two different groups of patients and better guide decision making for TVR, optimise timing of TVR and reduce futility of the procedure.REC name
Wales REC 6
REC reference
24/WA/0273
Date of REC Opinion
9 Oct 2024
REC opinion
Further Information Favourable Opinion