Predicting Recovery from Surgical Revascularisation in poor ventricles
Research type
Research Study
Full title
Predictors of Functional Recovery from Surgical Revascularisation of Poor Ventricles
IRAS ID
251280
Contact name
Charlotte Manisty
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2018/10/74, Data Protection Office; FS/18/83/34025, BHF CRTF reference; MGU0422, Barts Charity reference
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
Heart Failure is a major global health problem. Often it's caused by coronary disease, narrowings or complete occlusions of the arteries supplying the heart. One of the most effective treatments is coronary artery bypass graft surgery. However, many undergoing this surgery already have weak hearts which increases the risk of the operation, and potentially impacts on the success of surgery. Indeed, such patients undergoing bypass surgery have worse outcomes, long ITU stays, higher cost to the NHS and their symptoms may not fully resolve. The reasons for this are not fully understood. We do know however, that bypass grafts fail in about 1 in 7 patients early (within 1 year) and that some degree of additional damage to the heart is caused by the operation itself in almost half patients. These may contribute to bad outcomes.
At Barts Heart Centre we do approximately 200 bypass operations a year in such patients. We now have major technological advances in cardiac imaging, specifically in cardiac CT and MRI which can be used to better understand what determines the outcome of surgery. Through collaboration between specialists in cardiology, cardiac imaging, cardiothoracic surgery and medical physicists we plan to utilise this technology to answer these questions, addressing them from different clinical perspectives and focusing on patient-centred outcomes. In 100 patients we will do these tests before and after surgery to identify which grafts block, why and what causes heart damage at surgery and which factors determine whether the heart can recover.
By better understanding these mechanisms, bypass grafting can be improved and better targeted so our patients facing surgery can have better care.
REC name
London - Harrow Research Ethics Committee
REC reference
19/LO/0215
Date of REC Opinion
21 Feb 2019
REC opinion
Favourable Opinion