Predicting exercise duration in patients with HCM V1

• Research type

  Research Study

• Full title

  Predicting exercise duration in patients with hypertrophic cardiomyopathy

• IRAS ID

  318073

• Contact name

  Gemma Bassindale

• Contact email

  gemma.bassindale@nhs.net

• Sponsor organisation

  Leeds Teaching Hospitals Trust

• Duration of Study in the UK

  2 years, 4 months, 30 days

• Research summary

  Hypertrophic cardiomyopathy (HCM) is the most common inherited condition of the heart meaning it can be passed on in families. Patients with this condition have a thickening of the heart muscle and this thickening can cause symptoms for some patients. The thickened heart muscle can block blood trying to leave the heart and this can make patients dizzy, breathless and occasionally they can faint. The thickened heart muscle can also make the heart stiffer and that can lead to symptoms of heart failure including reduced exercise duration, breathlessness and fatigue. In patients with symptoms, we can use heart ultrasound to try and understand how the thickening of the heart is affecting the blood from leaving the heart and to measure how stiff the heart is.
  Changes in the heart can be very subtle in HCM and it is not always clear from the ultrasound what is causing symptoms and this can lead to delays in getting the right medication. New more sensitive ways of looking at how the heart contracts both at rest and on exercise may be able to help us identify why patients with HCM have symptoms. This study will look at using these new ultrasound measurements in patients with HCM and reduced exercise duration. We will be looking at exercise duration in these patients because we know that patients stop exercising when they have their symptoms and this is a way of understanding the point at which symptoms start. The study will involve inviting patients to have a heart ultrasound scan at rest and during exercise to see whether these new ultrasound measurements are related to exercise duration.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  23/EE/0132

• Date of REC Opinion

  23 May 2023

• REC opinion

  Favourable Opinion