PREDICT-SLD
Research type
Research Study
Full title
Precision approaches to diagnosis and management within Steatotic Liver Disease
IRAS ID
333709
Contact name
Ruairi Lynch
Contact email
Sponsor organisation
Tayside Health Board
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Fatty liver disease is becoming more common across the world, especially in people with “metabolic syndrome” - which includes people with conditions such as high cholesterol, high blood pressure, type 2 diabetes and obesity. Fatty liver can also be caused by alcohol intake.
People living with fatty liver disease are often unaware of it and there are few treatments for it. Some previous research studies have shown that different diabetes medicines may help lower fat, inflammation and scarring in the liver, as well as lower blood sugar levels, and so these medicines may be a good treatment for fatty liver disease.
We are undertaking a study in people with Type 2 Diabetes and fatty liver disease, who are due to start new diabetes treatments (with SGLT2i or GLP1-RA type medications) to see the effect the treatments have on reducing fat in their liver as a positive side effect. We are also interested in understanding if the amount of alcohol people drink has any effect on the ability of these medicines to reduce fat in the liver.
We are measuring the amount of fat in peoples’ liver, before and after their new diabetes treatments, using a special type of liver ultrasound (ultrasound is the type of scan used to look at babies in the womb in pregnancy). The special ultrasound is called a Fibroscan. We will also use results of blood tests which have already been collected. We will record information about peoples’ general health, lifestyle and other medications taken, and measure some features of peoples bodies (such as height, weight, hip and waist size), to try to understand if certain people respond differently to the medications than others.
REC name
West of Scotland REC 3
REC reference
24/WS/0176
Date of REC Opinion
12 Dec 2024
REC opinion
Favourable Opinion