Prediciting outcomes of intervention in PVD using MRI and CT and VaSSP
Research type
Research Study
Full title
Investigating the use of VaSSP software in analysing MRI and CT imaging to predict post-intervention flow rates in peripheral arterial disease
IRAS ID
124923
Contact name
Shervanthi Homer-Vanniasinkam
Contact email
Research summary
Peripheral Vascular disease is the cause of a significant amount of morbidity and mortality on the UK population. Currently the methods of revascularisation include angioplasty or bypass surgery, the decision between the two is largely made on the anatomy of the narrowed segment of artery assessed using cross-sectional imaging, e.g. MRI.
We plan to use a new MRI software program to help predict which intervention will likely yield the best result anatomically and importantly physiologically in terms of flow rates in the target vessels.
We plan to prosepectively enrol 40 patients with peripheral arterial disease requiring intervention. The aim is that 30 of these patients will undergo angioplasty and 10 will have a distal bypass procedure - this ratio based on the units activity over the past year. The decision as to which intervention they undergo will remain a clinical decision and the clinical team will have no information regarding any predictions on outcome generated by the research.
Data including demographics (anonymised), basic physiological data to include blood pressure, ankle-brachial pressure index, and radiological images will be collected. An additional ultrasound scan will be performed to attain blood velocity readings from several pre-designated points along the lower limb arterial tree. This data will then be provided to ARA who will enter it into their software programme. The hope is that the information generated will allow prediction of outcome in both groups and this will be compared with outcomes gathered for a 1 year follow-up period.REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
13/YH/0213
Date of REC Opinion
26 Jul 2013
REC opinion
Further Information Favourable Opinion