PREDEFine AKI: Pregnancy Definition of AKI

• Research type

  Research Study

• Full title

  Developing a pregnancy specific definition of Acute Kidney Injury

• IRAS ID

  299154

• Contact name

  Elisabeth Ralston

• Sponsor organisation

  King's College London

• Duration of Study in the UK

  1 years, 9 months, 31 days

• Research summary

  Acute Kidney Injury (AKI) is the sudden loss of kidney function that makes people more likely to develop long-term kidney and heart problems and can even lead to death. About one-third of AKI cases are preventable. The number of pregnant women with AKI has increased but we do not know how many or which women are affected. AKI is usually detected by measuring a reduction in urine production or rise in blood creatinine (marker of kidney function).

  The kidneys work about 50% harder during pregnancy making AKI more difficult to detect because creatinine levels are often low. I plan to find out what amount of change in creatinine means that someone has AKI.

  If we can work out which pregnant women are at risk of AKI then we can change their treatment early.
  This study was designed with a patient and public involvement group. The aims are to :
  - Define AKI in pregnancy
  - Find out the risk factors for AKI in pregnancy and how common it is.

  Data will be collected from the UK and Sweden on approximately 980,000 pregnancies to work out what level of change in creatinine is diagnostic of AKI in pregnant. I will then work out how often AKI occurs and any common risk factors using this new definition.

• REC name

  Wales REC 6

• REC reference

  23/WA/0272

• Date of REC Opinion

  28 Sep 2023

• REC opinion

  Favourable Opinion