PRECISION

• Research type

  Research Study

• Full title

  Impact of personalised cardiac anaesthesia and cerebral autoregulation on neurological outcomes in patients undergoing cardiac surgery

• IRAS ID

  322179

• Contact name

  Nuno Gomes

• Contact email

  nuno.gomes@usb.ch

• Sponsor organisation

  University Hospital Basel

• Duration of Study in the UK

  2 years, 8 months, 31 days

• Research summary

  Some of the most significant risks and consequences after heart surgery are complications affecting the brain. These can include confusion, impaired memory, weakened concentration, and stroke. A possible risk factor for such complications could be inadequate blood flow to the brain during the operation.
  The brain is one of the organs most sensitive to optimum blood flow, and each person has their own individual blood pressure ranges. Too low blood pressure may lead to reduced blood flow to the organs and too high blood pressure to increased strain on the vessels.
  A possible risk factor for such complications after heart surgery could be not enough blood flow to the brain during the operation. This study will investigate the possibility of determining the ideal blood pressure range during heart surgery by non-invasive measurement of blood flow to the brain using established technology like ultrasound and brain waves in a new way, in an attempt to establish a relationship between an individual’s blood pressure and their post-operative neurological status. This would have the potential to define an ideal blood pressure range for that individual, with the aim of minimising the risk of adverse postoperative outcomes.

• REC name

  South West - Frenchay Research Ethics Committee

• REC reference

  23/SW/0076

• Date of REC Opinion

  25 Jul 2023

• REC opinion

  Further Information Favourable Opinion