Pre-operative fluids in donor nephrectomy: a RCT
Research type
Research Study
Full title
Effect of preoperative intravenous fluid hydration on subclinical acute kidney injury: A randomised controlled trial.
IRAS ID
157826
Contact name
Marc Clancy
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The use of keyhole surgery in kidney donation began 1995, and this technique has rapidly become the predominant method of surgical removal of a kidney for transplantation. Despite improving the outcome for donors by reducing post operative pain and speeding up recovery, the technique exposes the kidney to additional stresses in terms of altered blood supply. As these stresses result from altered blood supply to the kidney, giving donors intravenous fluids before the operation may increase intraoperative blood flow to the kidney and therefore reduce any damage to the kidney and therefore reduce any damage to the kidney during the operation. Current measures of kidney function (serum creatinine and estimated glomerular filtration rate (eGFR)) are relatively insensitive measures of acute injury, with more sensitive measures desirable. Now a new test has become available which measures a protein in the blood (neutrophil-gelatinase associated lipocalin, N-GAL). This protein can be used to assess damage to the kidney that is too small to be detectable by other methods. This is important, as even small amounts of kidney injury may affect the functioning of the donated kidney and how long it lasts in the recipient.
This study is a randomised controlled trial which aims to compare two methods of fluid administration before the operation – actively giving fluid through a drip in the arm (three litres) during the overnight period before morning donation) with unlimited oral fluid as desired by the donor. It will compare these two methods by measuring the change in N-GAL.
REC name
West of Scotland REC 3
REC reference
14/WS/1160
Date of REC Opinion
27 Jan 2015
REC opinion
Further Information Favourable Opinion