PR Transfer- Predictors of Mortality Following PEG Insertion In Stroke
Research type
Research Study
Full title
Predictors of Mortality Following PEG (Percutaneous Endoscopic Gastrostomy) Insertion IN Stroke Patients
IRAS ID
127463
Contact name
A Manoj
Contact email
Sponsor organisation
Royal Liverpool And Broadgreen University Hospitals NHS Trust
Research summary
This is a retrospective observational study to investigate the predictors of mortality following PEG(percutaneous endoscopic gastrostomy, which is a tube that is inserted into the stomach for feeding and it is done with the help of a camera test) insertion in patients who have had a stroke. Patients who were admitted into the stroke unit in the Royal Liverpool and Broadgreen University Hospital between 2009 and 2013 who had a PEG insertion would be included. Following discussion with the statistician, we are looking at including about 120 patients for the study. The study will try to establish if the following factors are associated with a higher risk of mortality following PEG insertion at the end of 6 months :-
1. Serum albumin (protein secreted by the liver which indicates the nutritional status) at PEG insertion
2. Serum C-Reactive Protein (biochemical blood test that is raised with inflammation or infection) at PEG insertion
3. Chronic Obstructive Pulmonary Disease (COPD) - condition leading to damage to lungs due to smoking
4. Age
5. Diabetes mellitus
6. Charlson co-morbidity index - Predicts the 10 year mortality for a patient who may have a range of conditions. (See A13 for further explanation)
7. Body Mass Index at PEG insertion
8. Barthel index (Validated score which indicates the degree of disability following a stroke)
9. Classification of Stroke (Total Anterior Circulation Stroke (TACS), Partial Anterior Circulation Stroke (PACS), Lacunar Stroke(LACS)/ Posterior Circulation Stroke (POCS), and Haemorrhagic Stroke). These classification of strokes involve specific neurological deficits and usually indicate the severity of the stroke. (See A13 for further explanation)Their clinical management would not deviate from the usual clinical protocol for all ischaemic or haemorrhagic strokes.
This study would provide us with information that would identify the patients who would be deemed high risk and better able to provide them and the family with more information for them to make an informed decision.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
13/NW/0553
Date of REC Opinion
26 Sep 2013
REC opinion
Further Information Favourable Opinion