PPG Global
Research type
Research Study
Full title
Pullback Pressure Gradient (PPG) Global Registry
IRAS ID
310176
Contact name
Carlos Collett Bartone
Contact email
Sponsor organisation
Cardiovascular Center Aalst
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 5 months, 31 days
Research summary
Coronary angiography is a procedure where contrast dye is injected into the blood vessels that supply the heart, and x-rays are used to visualise any narrowings. By placing a wire with a pressure sensor inside the blood vessel during angiography, doctors can measure how severe these narrowings are. We know that performing this measurement improves patient outcomes whilst reducing healthcare costs.
However, the information that the pressure wire provides is difficult to interpret. Two doctors may reach two different conclusions when looking at the same data. A new and simpler way of presenting this information has been developed. This is called the Pressure Pullback Gradient (PPG) index. The PPG index provides doctors with a number between 0 and 1 to describe the distribution of narrowings within a blood vessel. Different patterns of narrowings may do better with different treatments, such as stents or bypass surgery.
This study will see how accurate the PPG index is in predicting the result of stenting, how well patients do in the long term, as well as how doctors use the information that it provides. It will recruit 982 participants worldwide who are having a coronary angiogram with a pressure wire measurement. They will be followed up for 3 years, during which information about their symptoms and health outcomes will be collected yearly.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
23/EE/0141
Date of REC Opinion
28 Jun 2023
REC opinion
Further Information Favourable Opinion