PPALM - Palm oil and Pentoxifylline Against Late Morbidity

  • Research type

    Research Study

  • Full title

    Randomised double-blind controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline (PTX) in patients suffering long-term adverse effects of radiotherapy for pelvic cancer

  • IRAS ID

    112878

  • Contact name

    Alexandra Taylor

  • Contact email

    alexandra.taylor@rmh.nhs.uk

  • Sponsor organisation

    Clinical Research and Development, Royal Marsden NHS Foundation Trust

  • Eudract number

    2012-004211-31

  • Clinicaltrials.gov Identifier

    112878, CSP

  • Research summary

    Side effects are common after treatment with radiotherapy for tumours in the pelvis and can affect the way the bowel and urinary system work as well as causing sexual difficulties, skin damage and bone problems. Problems in the bowel, bladder, sexual organs and skin mostly result from thickening of the tissues in response to radiotherapy, a process called “fibrosis”. Fibrosis often worsens over time.

    There has been progress in treating bowel symptoms which usually are the worst problem after radiotherapy. However, even after receiving the best possible treatments, while many patients are better, they are often not cured of all their difficult problems.

    For some years, it has been hypothesised that if fibrosis could be treated then symptoms would improve. Recent research in laboratory animals has suggested that an effective treatment for radiation-induced fibrosis is combination therapy with a drug called Pentoxifylline together with a nutritional supplement containing gamma-tocotrienol (Tocovid SupraBio), a substance derived from palm oil. Both of these agents are simple to take and side effects are rare.

    This study will recruit volunteers who continue to have difficult side effects after previous radiotherapy to the pelvis despite receiving the best treatments available from a unique clinic at The Royal Marsden which has pioneered treatment for bowel problems after radiotherapy. Two out of every three volunteers who take part, will be randomly assigned to treatment with Pentoxifylline and Tocovid SupraBio, while one out of three will receive dummy pills. Neither the patients nor the staff assessing them will know which treatment they have been given. Volunteers take the active treatments or dummy tablets for a year and will be assessed regularly while on treatment and for a year afterwards. This study will show whether active treatment is more effective than dummy pills in improving the symptoms caused by radiation-induced fibrosis.

  • REC name

    London - Central Research Ethics Committee

  • REC reference

    14/LO/1122

  • Date of REC Opinion

    20 Aug 2014

  • REC opinion

    Further Information Favourable Opinion