POTION Study
Research type
Research Study
Full title
POlypharmacy in hearT failure: Investigating the relatIONship between treatment and outcomes. - POTION Study.
IRAS ID
278426
Contact name
Janine Beezer
Contact email
Sponsor organisation
Newcastle University
Duration of Study in the UK
4 years, 5 months, 1 days
Research summary
Aim
This research aims to understand the relationships between patients with heart failure, when the heart is unable to work effectively, who take multiple medicines, usual five or more, known as polypharmacy. Including the impact on patient outcomes, defining appropriate polypharmacy and scoping of an intervention to tackle polypharmacy consisting of 4 work packages (WP).
WP 1
To characterise polypharmacy in the different types of heart failure, understand occurrence and explore factors that influence polypharmacy in patients with heart failure.
I plan to retrospectively review data for patients admitted to hospital with heart failure and compare the polypharmacy observed in different heart failure types, quantify the differences and highlight factors that influence polypharmacy, then use this data to understand the relationship between polypharmacy and outcomes such as, readmission to hospital and death.
WP 2
Explore the effects polypharmacy has on people with heart failure and how it impacts daily life and to explore health professionals' views on how polypharmacy impacts on heart failure treatment decisions.
I plan to use informal interviews with patients/carers and specialist heart failure health professionals to explore their views and experiences.
WP 3
To gain agreement on what appropriate polypharmacy for people with heart failure should be.
I plan to develop a group of specialist professionals, alongside other healthcare professionals and patients and gain agreement on appropriate polypharmacy in heart failure patients, informed by the findings from WP 1 and 2.
WP 4
To co-produce an intervention to improve polypharmacy in heart failure
Patients and carers alongside healthcare professionals, will be invited to workshops to co-produce an intervention to improve prescribing in heart failure, using information from work packages 1-3.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
21/EE/0239
Date of REC Opinion
2 Dec 2021
REC opinion
Further Information Favourable Opinion