POPular PET TAVI
Research type
Research Study
Full title
The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration
IRAS ID
327157
Contact name
Marc Dweck
Contact email
Sponsor organisation
St. Antonius Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Replacement heart valves can be made from animal tissue (for example from pigs or cows) and are placed within a metal frame. This is foreign material to the body, and small blood clots have been shown to stick to replacement heart valves. In the vast majority of cases, this does not cause any problems. However over many years, wear and tear of the valve can occur, causing the replacement heart valve to become narrowed or to leak. It is unknown if small blood clots make wear and tear of replacement aortic valves more likely or not, and whether there are differences in signs of wear and tear between different types of TAVI valves. Our goal is to better understand the processes of what causes and accelerates the wear and tear of these replacement heart valves.
To do this, we'll use specialised imaging tests including a state of the art scan called a PET-CT scan and an ultrasound scan called an echocardiogram, to spot early signs of valve wear and tear. We will invite patients who had this valve procedure five years ago to come to the hospital for these heart scans. Once the scans are done, their part in the study is over, and no more follow-up is needed. We aim to continue the research until 180 patients complete the heart scans, which we estimate will take about two years.
REC name
North of Scotland Research Ethics Committee 1
REC reference
24/NS/0042
Date of REC Opinion
29 Apr 2024
REC opinion
Further Information Favourable Opinion