POPPET Study (PK of continuous infusion of Pip/Taz in children)
Research type
Research Study
Full title
POPPET Study - Pharmacokinetics of continuous administration of Piperacillin/Tazobactam to children using an elastomeric pump
IRAS ID
180608
Contact name
Daniel Hawcutt
Contact email
Sponsor organisation
The University of Liverpool
Eudract number
2015-002644-14
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
POPPET is a study looking at the drug concentrations of Piperacillin/Tazobactam, an antibiotic, when it is given as a continuous infusion to children.
Giving Piperacillin/Tazobactam as a continuous infusion via an elastomeric pump is in the process of being adopted as standard of care for patients admitted to the oncology unit with a temperature and low white blood count: febrile neutropenia. Using elastomeric pumps has been shown to reduce hospital stay and more acceptable to patients as they can continue receiving the antibiotic at home, unlike with a four times daily intermittent infusion. Due to the way Piperacillin/Tazobactam works, continuous infusion should increase the effectiveness of the drug. While there is a lot of evidence for the use of elastomeric pumps with Piperacillin/Tazobactam and of Piperacillin/Tazobactam administered by continuous infusion in adults, there is little evidence in children.
The POPPET Study aims to take blood samples for Piperacillin/Tazobactam concentrations from pre-consented oncology patients who present to Alder Hey Children’s Hospital with febrile neutropenia. Blood samples will be taken during intermittent and continuous dosing phases alongside their normal clinical care, and sent to the University of Liverpool for analysis. The children will only receive treatment as per the normal pathway of care. The study hopes to determine the concentrations of Piperacillin/Tazbactam achieved when administered by continuous infusion in children.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
15/NW/0500
Date of REC Opinion
21 Jul 2015
REC opinion
Further Information Favourable Opinion