POLO
Research type
Research Study
Full title
SERIAL CONCENTRIC DERMAL BIOPSY MODEL OF ACUTE WOUND HEALING
IRAS ID
159249
Contact name
Keith Harding
Contact email
Sponsor organisation
Cardiff University
Clinicaltrials.gov Identifier
SPON1348-14, Cardiff University Sponsorship Number
Research summary
The human dermal acute wound healing response is a complex process consisting of several co-ordinated, but overlapping, diverse biological processes. The fundamental biological processes occurring in dermal healing are similar to those involved in embryonic development and development of a new tumour, which reinforces the necessity for studying wound healing beyond the obvious requirements for improving the treatment of wounds. Wound healing research has been affected by two major limitations; i) the lack of an appropriate animal model, that is truly representative of wound healing in humans, ii) a lack of a controlled, well defined human model of acute dermal wound healing.
In this study we aim to determine the usefulness of serial concentric dermal punch biopsies in normal human volunteers as a controlled model system in which to examine normal dermal healing. Our secondary aim is to use this system to analyse the early events occurring in normal dermal healing in a controlled system. The biological processes involved in human wound healing are of fundamental importance. There is, however, a fundamental lack of data within the scientific and clinical literature that addresses key cellular and molecular biological aspects of the dermal healing process in humans. Variations in patient and clinical criteria have been a potential major source of the variability of pre-existing data.
This study, in healthy, young volunteers, will facilitate inter-patient comparisons of cell populations, collagen and integrin gene expression; and the course of re-epithelialisation.
REC name
Wales REC 3
REC reference
14/WA/1109
Date of REC Opinion
15 Sep 2014
REC opinion
Unfavourable Opinion