Pnh clones detection in MDS patients using flow cytometry
Research type
Research Study
Full title
Detection of Paroxysmal Nocturnal Haemoglobinuria (PNH) Clones in patients with Myelodysplastic Syndrome (MDS) by high sensitivity flow cytometry
IRAS ID
107945
Contact name
Faith Wright
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Research summary
The main aim of this project is to design the method of detection of PNH clones in MDS by high sensitivity flow cytometry and establish it in the laboratory.
Current studies have shown that PNH cell are present in a majority of MDS patients and therefore detection of this clones may help physicians detect and identify undiagnosed PNH in these disease condition who may be more likely to respond to immunosuppressive drugs.
The PNH disease is rare, but identification of the PNH clones in the MDS patients may impact the mode of treatment and therefore may impact on quality of life and survival for any individual patient.
Currently the test available in my hospital which is one of the specialist hospital dealing with oncology and haematology patients is the screening of PNH using red cell and my project is intended to design and establish the test to screen for small PNH clones using granulocytes and monocytes on patients with MDS in the hospital as this will be of great benefit to the clinicIans and the patients.REC name
London - Stanmore Research Ethics Committee
REC reference
13/LO/1818
Date of REC Opinion
19 Nov 2013
REC opinion
Favourable Opinion