PLORAS version 1
Research type
Research Study
Full title
Predicting Language Outcome and Recovery After Stroke
IRAS ID
133939
Contact name
Cathy Price
Contact email
Research summary
The aim of the study is to provide a clinical protocol that will Predict Language Outcome and Recovery After Stroke (PLORAS). The system we are developing takes a structural brain image of a new patient with language difficulties (aphasia) and produces probabilistic estimates of long term outcome, based on whether, when, and in what respects, other patients with “matching” lesions recovered their speech and language abilities [1].
The project rests on a database that records three types of information from many hundreds of stroke patients: language scores (from standardised assessment), structural MRI, and demographic information (age, time post stroke etc). Critical lesion sites for aphasic symptoms are identified by linking structural MRI and language scores. A combination of all data types then enters the PLORAS system, which predicts recovery from aphasia in new patients.
In order to be successful, we need to study large numbers of patients who have had a stroke, some of whom have continuing problems with their language and some who don’t. The information from this study will enable us to make predictions about likely recovery patterns in patients who suffer strokes in the future. This will help guide both clinical and experimental therapeutic interventions.REC name
London - Queen Square Research Ethics Committee
REC reference
13/LO/1515
Date of REC Opinion
22 Jan 2014
REC opinion
Further Information Favourable Opinion