Plerixafor kinetics and radiolabelled neutrophils (v1)
Research type
Research Study
Full title
Investigation of the physiological effects of CXCR4 inhibition on the kinetics of radiolabelled neutrophils in man (EPIGRAPH)
IRAS ID
173708
Contact name
Edwin Chilvers
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and The University of Cambridge
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Specific white blood cells play a major role in the mechanism of acute lung injury. This condition, which is commonly encountered in patients in the intensive care, is characterised by inflammation and an increase in circulating pre-activated white blood cells. These activated blood cells collect in the blood vessels of the lung and frequently cause damage; however very little is known about the mechanisms underlying the capture or release of these cells in the lung. From previous studies in mice it was found that plerixafor (a blocker) plays an important role in the collection and release of white blood cells within the blood vessels.
We would like to study the effect of plerixafor administration on the behaviour of the white blood cells in the circulation of healthy volunteers, in particular the effects on how they collect in the lungs, liver and spleen. To do this we will recruit healthy volunteers who will be given a subcutaneous injection of the drug or a placebo, randomised by the study doctor. One hour following this we will use the established technique of re-injecting radiolabelled autologous blood cells into the donor while they are being scanned (SPECT-CT). We will also take regular blood samples to determine how long the re-injected cells remain in the circulation. These scans and blood samples will be repeated on day 2 and day 3. This is a safe technique and is the basis for the white cell scan, which is in routine clinical use in the hospital's nuclear medicine department to find hidden infections.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
15/EE/0176
Date of REC Opinion
1 Jun 2015
REC opinion
Unfavourable Opinion