Platelet Rich Plasma with Hyaluronic Acid in Knee Osteoarthritis
Research type
Research Study
Full title
The use of Platelet Rich Plasma with Hyaluronic Acid in Knee Osteoarthritis
IRAS ID
172992
Contact name
Gorav Datta
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Eudract number
2015-001576-21
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
This trial aims to evaluate the results of a combined knee injection of HA (Hyaluronic acid) and PRP (Platelet Rich Plasma) against the traditional steroid knee injection in the treatment of knee osteoarthritis. Patients will be randomised into which injection they receive. Outcome scores will be collected for a total of 4 months following the injection and results compared between the two groups.
Knee osteoarthritis is a very common condition. Patients with mild symptoms may take oral painkillers, and patients with severe symptoms may result in undergoing knee replacement surgery. A common treatment for mild to moderate symptoms not requiring surgery is a knee injection consisting of a combination of a steroid and local anaesthetic. The effect of steroid injections are usually short-lived (weeks) and repeated injections can damage the joint cartilage so are not advisable. Newer injections in the knee consisting of synthetically produced Hyaluronic Acid (HA) have been used for over 10 years with reasonable outcomes in patients with mild to moderate symptoms of knee osteoarthritis. More recently, Platelet Rich Plasma (PRP) has been used to inject into joints and treat osteoarthitis. PRP is derived from the patient's own blood sample and concentrating by a centrifuge and re-injecting back into the patient. However, little data exits regarding its efficacy.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
15/EE/0449
Date of REC Opinion
24 Dec 2015
REC opinion
Unfavourable Opinion