Platelet -omics in Acute Myocardial Infarction
Research type
Research Study
Full title
Differentially Expressed Proteins and micro-RNA in Phenotypically Varied Platelets: How Do Variations in Mean Platelet Volume Occur, and How Does It Confer Cardiovascular Risk?
IRAS ID
180347
Contact name
Abhishek Joshi
Contact email
Sponsor organisation
Kings College, London
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Tiny particles called platelets in human blood are responsible for forming clots. When platelets form a blood clot, they can block an artery supplying the heart and cause a heart attack. Some people have platelets that are, on average, bigger than others’. This is associated with a higher risk of having a heart attack, but there are no treatments that can alter this. We will apply new laboratory techniques to analyse the composition of these platelets, and to see what molecules are different in platelets before and after the heart attack. We will then search for molecules, which contribute to the size of the platelet and compare them with the same measurements in patients having bypass surgery, to see what is different about heart attacks.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
16/LO/1126
Date of REC Opinion
27 Jun 2016
REC opinion
Favourable Opinion