Plasma,Serum & DNA bank from patients with antiphospholipid antibodies

• Research type

  Research Tissue Bank

• IRAS ID

  2204010

• Research summary

  Collection of Plasma, Serum and DNA from patients who have antiphospholipid antibodies.

• REC name

  London - Central Research Ethics Committee

• REC reference

  17/LO/0269

• Date of REC Opinion

  1 Mar 2017

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Samples collected will be stored as a biobank of plasma, serum and DNA.

  Data will have personal identifiers, medical history, treatment information, and family history. Samples collected will be from suitable patients identified from outpatient clinics, by the research team following collection of signed consent forms. Consent forms will be kept in a restricted area in an office/laboratory which is only accessible via a keycard, and is monitored by CCTV 24/7hrs.

  Samples will be processed and stored at the correct temperatures in locked freezers to form the biobank, in the Department of Thrombosis and Vascular Biology within the Rayne Institute which is a restricted area and only accessible via a keycard, and is monitored by CCTV 24/7hrs.

• Research programme

  Antiphospholipid syndrome (APS) is defined as the association of antiphospholipid antibodies (aPL) with arterial or venous thrombosis or pregnancy morbidity. These antibodies are heterogeneous in their targets and conventionally are detected by the presence of either anticardiolipin (aCL) antibody and/or lupus anticoagulant (LA). There is limited understanding of how these antibodies cause disease. Blood from patients with APS will be collected for storage as a biobank of plasma, serum and DNA, so that studies can be conducted to understand the pathogenesis of the disease. Patients will be recruited as they attend the Haematology, Thrombosis and Haemostasis and Lupus Unit clinics. Research undertaken will involve trying to further understand pathogenic mechanisms of the disease in addition to identifying potential biomarkers.

• Storage license

  12522

• RTBTitle

  Collection of Plasma, Serum and DNA from patients who have antiphospholipid antibodies.

• Establishment organisation

  St Thomas' Hospital, Thrombosis and Vascular Biology Unit

• Establishment organisation address

  4th Floor, Lambeth Wing, Rayne Institute

  Westminster Bridge Rd,

  SE1 7EH