PIRS Version 1

• Research type

  Research Study

• Full title

  Preoperative Imaging of Retroperitoneal Sarcomas

• IRAS ID

  117562

• Contact name

  Christina Messiou

• Contact email

  christina.messiou@rmh.nhs.uk

• Sponsor organisation

  The Royal Marsden NHS Foundation Trust

• Research summary

  This is a prospective observational study in which patients with untreated retroperitoneal sarcoma will have Magnetic Resonance Imaging prior to surgery.In addition, patients who will be undergoing pre-operative radiotherapy will have an additional MRI scan at two weeks post radiotherapy. For both groups, the MR images will be correlated with tumour pathology.
  We aim to demonstrate that Magnetic Resonance Imaging can provide a more accurate assessment of tumour volume than standard clinical CT imaging. Furthermore, that MRI techniques can be used to identify areas of altered oxygenation, cellularity and perfusion which change in response to radiotherapy before tumour shrinkage occurs, thus aiding surgical planning.

• REC name

  East of England - Cambridge East Research Ethics Committee

• REC reference

  13/EE/0186

• Date of REC Opinion

  4 Jul 2013

• REC opinion

  Further Information Favourable Opinion