PIBCAP
Research type
Research Study
Full title
Pneumonia Investigation Bundle to Guide Therapy for Hospitalised Community Acquired Pneumonia (PIB CAP Study)
IRAS ID
237740
Contact name
Adam Hill
Contact email
Duration of Study in the UK
3 years, 1 months, 29 days
Research summary
There is an international drive to simplify antibiotic treatments to stop side effects from antibiotics and to stop the development of superbugs.
Pneumonia is an infection of the lung affecting 5 to 11 people out of 1,000 in the population. About 9% of patients admitted to hospital with pneumonia will die. Prompt and appropriate antibiotic treatment is needed to cure the pneumonia. International guidelines suggest using a combination antibiotic treatment for 7 to 10 days for patients admitted with pneumonia. However it is not completely known what antibiotics to prescribe or for how long antibiotic treatment is needed.
Tests currently used in the NHS can identify the cause of pneumonia in only 39% of patients. In addition, traditional methods to investigate pneumonia in the NHS take too long to give an answer. In many cases clinicians do not have enough information to confidently shorten or reduce antibiotic treatments.
We have developed a molecular test that identifies the cause of pneumonia in 87% of patients. Our test is very quick and we can have a result within a few hours. We call our test a "PIB CAP bundle".
We will invite patients who have been admitted to hospital with pneumonia to enrol onto our study. Participants will be randomised to receive either (1) the usual NHS tests and normal treatment for pneumonia, or (2) the PIBCAP molecular test and customised antibiotic treatment.
The main aim of the study is to determine if the PIB CAP test can reduce the amount of antibiotics prescribed without any undesirable clinical side effects. We will count up how much antibiotic treatment each participant had, including any additional antibiotics that might have been needed after initial treatment. After 30 days each participant will have medical examinations and tests to see if it is safe to treat pneumonia with less antibiotics.REC name
Scotland A: Adults with Incapacity only
REC reference
18/SS/0125
Date of REC Opinion
17 Oct 2018
REC opinion
Further Information Favourable Opinion