Physical activity in Familial Hypercholesterolaemia
Research type
Research Study
Full title
Physical activity in Familial Hypercholesterolaemia: An exploration of levels, preferences and barriers.
IRAS ID
336096
Contact name
Jillian Webster
Contact email
Sponsor organisation
York St John University
Duration of Study in the UK
0 years, 6 months, 31 days
Research summary
Familial Hypercholesterolaemia (FH) is an inherited condition which leads to exceptionally high cholesterol levels, often double and occasionally, four times those of the general population (BHF, 2018). One in 250 of the general population has FH but many are as yet undiagnosed, leaving individuals at high risk of developing cardiovascular disease and dying suddenly at a premature age from a heart attack. On average, the untreated condition shortens life expectancy by 20-30 years, although early treatment through statins is likely to be effective in preventing cardiovascular disease. However, this presents a financial implication through pharmacological interventions. Whereas, lifestyle modifications (such as physical activity (PA), smoking cessation and alcohol reduction to recommended limits), dietary management and careful monitoring can allow people with FH to achieve the same life expectancy as those without the conditionIdentifying what impact PA, and potential mechanisms, by which PA could reduce cardiovascular disease within the FH and non-FH populations is a vital part of the management of this genetic condition. There are currently no targeted regimes for the FH population and this research would complement the provision of precision lifestyle and dietary advice to this group of people, enhancing the existing service and supplement current pharmaceutical therapies. The aims of the study will be to explore how participants are meeting the recommended guidelines and establish preferences for, barriers to, and determinants of PA in this population.
REC name
East of England - Essex Research Ethics Committee
REC reference
24/EE/0096
Date of REC Opinion
10 May 2024
REC opinion
Further Information Favourable Opinion