PHOTO: Health Economics Time Trade-off Study
Research type
Research Study
Full title
PHOTOdynamic versus white light-guided treatment of non-muscle invasive bladder cancer: Health Economics Time Trade-off Study to value short term quality of life loss post treatments
IRAS ID
214634
Contact name
Rakesh Heer
Contact email
Sponsor organisation
Newcastle Upon Tyne Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
8427, IRAS Reference
Duration of Study in the UK
1 years, 2 months, 30 days
Research summary
Over 10,500 cases of bladder cancer are diagnosed each year. The PHOTO trial aims to determine whether blue light (photodynamic) surgery is better than conventional surgery in the treatment of bladder cancer and whether its use is worthwhile for the NHS. As part of this study data on quality of life is being collected at 6 monthly intervals. However because some of the side effects of treatment are relatively short-lived there is a risk that the interval of data collection will miss changes in quality of life.
This study uses a 'Time Trade-off' method. 'Health States' (cards with lists of symptoms and side-effects relating to the 2 types of surgery) will be developed to represent a range of scenarios from ‘mild’ to ‘severe’. Participants will be asked to state preferences for different health states lasting varying lengths of time. This data will be used alongside the 6-monthly quality of life data from the trial and will help to give us a more complete understanding on the likely impact on quality of life of photodynamic and standard surgical treatment for bladder cancer.REC name
South Central - Berkshire B Research Ethics Committee
REC reference
17/SC/0519
Date of REC Opinion
20 Oct 2017
REC opinion
Further Information Favourable Opinion