PHOENIX-f
Research type
Research Study
Full title
PHOENIX-Feasibility: Picking up Hidden Osteoporosis Effectively during Normal CT Imaging Without additional X-rays
IRAS ID
259482
Contact name
Ken Poole
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
3 years, months, days
Research summary
Osteoporosis is a disease that weakens bones by reducing their density, making them fragile and more likely to break (fracture). Osteoporosis particularly affects the spine and hips causing 200,000 spine fractures per year in men and women in the UK. There are several effective treatments for osteoporosis but a vertebral fracture can feel like ordinary backache and a patient may have many broken bones in their back before they are diagnosed and given treatment. Identifying osteoporosis earlier in the course of the disease means that bone strengthening treatment can be given and fractures may be prevented.
In PHOENIX-f patients coming for a CT scan of their abdomen or pelvis for many reasons will be asked to join the study. If they agree, they will be given a questionnaire on their bone health to fill in and return and, if appropriate, their CT images will then be reviewed using new software to identify osteoporosis in their bones. This new software makes it easy to measure bone density quickly and identify vertebral fractures from CT images (from any CT scanner). This will enable earlier diagnosis and treatment and potentially prevent future fractures. Two questionnaires will be sent to participants, the first shortly after recruitment to gather baseline information, and the second after 12 months for follow up.
The PHOENIX –f study is a feasibility study carried out locally to assess whether a national trial could be developed from it. The main outcomes measures are:
• Whether a sufficient number of participants come forward.
• Follow-up questionnaire return rate of at least 75% at 12 monthsREC name
East of England - Cambridge East Research Ethics Committee
REC reference
19/EE/0176
Date of REC Opinion
28 Jul 2019
REC opinion
Further Information Favourable Opinion