PHENOTYPE [COVID-19]
Research type
Research Study
Full title
PHenotyping patiENts admitted to hospital with cOvid-19 infection and idenTifYing Prognostic markErs
IRAS ID
284497
Contact name
Pallav Shah
Contact email
Sponsor organisation
Chelsea and Westminster Hospital NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
COVID-19 has resulted in significant morbidity and mortality with an excess of 30 000 deaths in the UK alone. The clinical presentation varies from mild respiratory symptoms to respiratory failure requiring ventilation and death. \n\nThe long-term sequelae of COVID-19 infection has not been studied. Studies from MERS and SARS suggest chronic lung problems related to infection. Furthermore, COVID-19 infection increases the likelihood of embolism (clots), which can also result in long-term complications. There is evidence to suggest that COVID-19 infection can affect the kidneys, heart, gastro-intestinal system and have an impact on quality of life, clinical frailty and mood. \n\nThe aim of this cohort study is to follow up patients who have had COVID-19 infection to see what and whether they develop heart, lung, kidney or mood-related complications as a consequence. Patients will be reviewed during their follow up appointments, up to a year post discharge, and undergo blood sampling at each clinic visit to look at various parameters including genetic profiles. Patients can also take part in a semi-structured interview to further explore issues such as the impact of health behaviour on disease burden. We hope that this cohort study will provide useful data to inform future diagnostic and follow up pathways and improve clinical care.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
20/YH/0186
Date of REC Opinion
17 Jun 2020
REC opinion
Further Information Favourable Opinion