PET/CT treatment monitoring in Hodgkin Lymphoma.

• Research type

  Research Study

• Full title

  Treatment monitoring using FDG-PET/CT and FLT-PET/CT in patients with Hodgkin Lymphoma.

• IRAS ID

  35909

• Contact name

  Silvia Montoto

• Eudract number

  2009-017587-16

• ISRCTN Number

  n/a

• Research summary

  This study aims to find a method utilising Positron Emission Tomography (PET) combined with computerised tomography (CT) (PET/CT) for predicting response to chemotherapy after receiving only one cycle of treatment. Patients diagnosed with Hodgkin Lymphoma receiving ChlVPP (Chlorambucil, vinblastine, prednisolone, Procarbazine) chemotherapy either as initial treatment or second line treatment will be invited to participate. A PET scan uses a radioactive drug to produce images of the body with areas of activity in malignant tissue delineated. In this study two types of radioactive drug will be used to perform a PET scan. These are called FDGflurodeoxyglucose) and FLTflurothymidine). FDG-PET/CT scans are already in routine use to assess the spread of cancer before and after chemotherapy but are not routinely used to predict the effectiveness of chemotherapy during treatment. We believe FLT would be better at predicting response therefore we aim to compare both, FDG and FLT. Predicting response to chemotherapy early (after one cycle of treatment)is vital as it could allow the discontinuation of ineffective treatment avoiding side effects in those responding less well and switching to alternative treatment, while those who are responding could continue on their current treatment. However this is a feasibility study and patients' treatment will not be altered by the results. Following a screening visit, patients will have one FDG and one FLT-PET/CT before starting treatment, after completing one cycle and after completion of chemotherapy treatment. Data collected from these six scans for each patient will be analysed. There after data on progression free and overall survival will be obtained from medical records.

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  10/H0720/76

• Date of REC Opinion

  30 Nov 2010

• REC opinion

  Further Information Favourable Opinion