PET-MRI Imaging in Patients with Symptomatic Carotid Artery Stenosis.
Research type
Research Study
Full title
Hybrid 18F-fluoride Positron Emission Tomography-Magnetic Resonance Imaging in Patients with Symptomatic Carotid Artery Stenosis.
IRAS ID
218086
Contact name
David Newby
Contact email
Sponsor organisation
University of Edinburgh Research Governance, ACCORD
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Hardening of the neck vessels (carotid arteries) caused by fatty deposits called 'plaques' is a common cause of strokes. Over time plaques can burst or may lead to a severe narrowing (stenosis) of the neck artery. When plaques burst, small clots or fatty particles (called microemboli) break off, block brain vessels and lead to a stroke. We have an incomplete understanding of the processes that cause hardening of the arteries, development of small clots and are unable to predict who will have a stroke. Recently using Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI) scans it has become possible to take pictures that highlight certain processes in the neck arteries. Therefore, we would like to evaluate the ability of PET-MRI scans to examine what is going on in these arteries. This may give us valuable insight into why hardening of the arteries develops. It may also help us identify future patients at particular risk of stroke. Finally, it may also pave the way for the development of new treatments for these conditions.
REC name
South East Scotland REC 02
REC reference
17/SS/0097
Date of REC Opinion
3 Aug 2017
REC opinion
Further Information Favourable Opinion