Persona MC vs Attune TKR (PERTUNE) study
Research type
Research Study
Full title
Functional comparison of two modern designs of total knee replacement - a gait cohort study comparing Persona MC to Attune total knee replacement
IRAS ID
241978
Contact name
Graham Chapman
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Arthritic conditions of the knee commonly cause pain and disability leading to a poor quality of life. Total knee replacement (TKR) is a commonly performed operation and provides patients with pain relief, return of function and an improved quality of life. Although considered a highly successful operation, up to 15% of patients remain unsatisfied with their outcome. One explanation is that TKR surgery often fails to accurately reproduce the normal motion and natural feeling of the human knee. To address this, implant manufacturers have recently concentrated on designing TKR implants that more closely match the shape of the bones of a naturally, healthy knee, known as medial congruent (MC) TKR, theoretically leading to improved functional outcomes.
This study aims to compare clinical and functional outcomes of a cohort of patients that have undergone a MC TKR to a similar cohort of patients that have undergone a conventional TKR and a cohort of control participants. Our null hypothesis is that there will be no difference in functional outcome between the two types of TKR. The primary outcome measure is knee extensor moment during stair descent. The extensor moment is a surrogate measure of knee stability. The secondary outcome measures are knee function measured by the Oxford Knee Score (OKS), the Knee injury and Osteoarthritis Outcome Score (KOOS) and the 2011 Knee Society Objective Knee Score (KSOKS), general health relayed quality of life measured by the Euro-Qol 5D (EQ5D) score and Forgotten Joint Score (FJS) and gait analysis.
The conclusions from this study can be used to guide clinical decision making and influence TKR manufacturers as they will help provide a greater understanding of the functional effects of using a MC TKR system. This will have implications on the direct clinical care of patients and will also have potential cost-savings implications during procurement processes.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0356
Date of REC Opinion
9 Jul 2018
REC opinion
Further Information Favourable Opinion