Peritoneal inflammatory responses in the injured abdomen
Research type
Research Study
Full title
The Role of Intestinal Peritoneum and Biologic Implants in Inflammatory Responses and Healing in the Injured Abdomen
IRAS ID
160798
Contact name
James Berry
Contact email
Sponsor organisation
University Of Manchester
Clinicaltrials.gov Identifier
15/LO/0490, NRES Committee London - City Road Hampstead
Duration of Study in the UK
1 years, 11 months, 26 days
Research summary
Peritoneal adhesions are bands of scar tissue that form between abdominal organs and abdominal wall. They are common following trauma, infection and surgery and may cause significant morbidity, often requiring further surgical treatment. This surgery is especially challenging following multiple operations in which the abdominal wall is compromised and may require reinforcement or replacement by prosthetic implant material. Although such implanted material is said to be inert, certain types of biological implants have been shown to cause particularly severe adhesions.
Peritoneal adhesions are a significant burden on the NHS and treating them is estimated to cost the NHS £67 million each year. Although adhesions seem to develop as a result of inflammation within the abdomen, the precise underlying mechanisms are not fully understood and there are still no reliable methods of adhesion prevention.
The proposed studies examine the role of the peritoneal lining in the coordination of the inflammatory responses that lead to adhesion formation, to identify potential future targets for preventative strategies.
The proposed studies will be undertaken in samples taken from patients undergoing elective abdominal surgery. Explanted peritoneal tissues will be cultured in the laboratory and exposed to a inflammatory stimulus from gut bacteria (lipopolysaccharide), as well as biological implants. Expression of key regulatory genes and proteins and the signalling pathways involved in the inflammatory response will be examined in these tissues.REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/0490
Date of REC Opinion
24 Mar 2015
REC opinion
Further Information Favourable Opinion