Perioperative Medicine-Metabolic Profiling Study (POM-MP) v1.0
Research type
Research Study
Full title
Perioperative Medicine - Metabolic Profiling Study ( POM - MP)
IRAS ID
297518
Contact name
John Whittle
Contact email
Sponsor organisation
University College London Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
250 million surgeries are carried out each year worldwide. 5% of surgeries are performed on "high-risk" patients who are at increased risk of postoperative complications or dying from surgery. Advanced age, low physical fitness, frailty, malnutrition and co-existing illness are significant predictors of adverse outcomes. Identification of these factors preoperatively can help guide medical optimisation. This study aims to explore the relationship between these risk factors and outcomes after surgery, focusing mostly on how the body uses the energy derived from different fuel sources (fat and sugar). The primary question we wish to answer is how the way the body uses fuel before surgery relates to outcomes after surgery.
The study will recruit higher-risk patients undergoing major abdominal surgery. Participants will undergo functional assessments that investigate the cardiorespiratory system and skeletal muscles. Blood samples will be taken to examine a panel of tests predicted to be related to perioperative complications that includes mitochondrial health. Frailty, health, nutrition and quality of life questionnaires will supplement the investigation.
Cardiopulmonary exercise testing (CPET) is a non - invasive measure of physical fitness. It is considered a link between heart and lung function and cellular health, (more precisely how efficiently the mitochondria- the batteries of the cell- work). We will use CPET, amongst other related tests, to help us understand how the body uses fuel when stressed. We will then follow the patient after surgery to see how their usage of fuels changes in the early postoperative period and how this reflects in changes in their body composition and mitochondrial health.
This will help us develop individualised preoperative risk assessment based on the baseline metabolic health of the patient. It will provide an in-depth understanding of the mechanisms resulting in complications and enable timely interventions.
REC name
Wales REC 3
REC reference
21/WA/0356
Date of REC Opinion
5 Jan 2022
REC opinion
Further Information Favourable Opinion