Perioperative Fluid Status in HPB Patients
Research type
Research Study
Full title
Assessment of Perioperative Fluid Status in Patients undergoing Hepatobiliary and Pancreatic (HPB) Surgery
IRAS ID
271216
Contact name
Michael Silva
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 3 months, 31 days
Research summary
Patients with liver and pancreas cancer undergo major surgical procedures in order to help cure their disease. Operations on the gastrointestinal tract often affect the way the body is able to manage body fluids. Too little fluid can cause dehydration. This in turn can affect multiple body systems including the kidneys and heart. Too much fluid can also affect the heart, as well as the lungs and other body systems. These effects can cause complications after surgery, delaying recovery.
Healthcare professionals rely on a number of measurements to assess the fluid status of patients. This in turn helps guide treatment (for example, the administration of fluid through a drip). None of the methods currently used measure fluid status directly.
Bioimpendence is a way of measuring the volume of water within the body. It measures how easily very small electrical currents pass through body tissues. It takes seconds to collect this information, and there are no harmful side effects.
It is not known how much total body fluid changes after these surgical procedures. In order to determine if BIA can help healthcare professionals manage fluids better, we first need to look at the changes that take place after surgery. This study will measure changes immediately before and on day 1, 3 and the day of discharge after surgery. We will then use these results to determine if BIA could be used to guide management in the future.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
22/SC/0412
Date of REC Opinion
24 Apr 2023
REC opinion
Further Information Favourable Opinion