Perineural invasion in cutaneous squamous cell carcinoma
Research type
Research Study
Full title
Prognostic significance of perineural invasion in cutaneous squamous cell carcinoma with regards to nerve diameter, pattern of invasion, anatomical location of involved nerve, distance of involved nerve from the advancing edge of the tumour and to the excision margin and determine the significance of perineural invasion in TNM staging.
IRAS ID
306957
Contact name
Kowsala Rajaratnam
Contact email
Sponsor organisation
Ashford and St Peter's Hospitals NHS Foudation Trust
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
Collect all cases of cutaneous squamous cell carcinoma(second commonest skin cancer) reported at St Peter’s Hospital from 2016 using code for skin and code for squamous cell carcinoma(skin cancer) from the hospital computer data. Among those special type of skin cancer(cutaneous squamous cell carcinoma)), select cases with tumour cells surrounding the nerve(perineural invasion) after going through all histology reports and categorise those cases into high and very high risk groups according to British Association of Dermatologist risk group category. Then further categorise according to the location of nerve invasion(tumour cells surrounding the nerve - perineural invasion), pattern of neural invasion(focal/complete) and measure the actual size of the involved nerve diameter and categorise diameter less than 0.1mm, 0.1-0.2mm, 0.2mm-0.3mm and >0.3mm.
Thereafter measure the depth of the nerve invasion from the skin layer, distance of nerve invasion from the advancing edge of the tumour and from the excision margin and also look for special type of nerve involvement. Follow up these cases for disease recurrence at local site or spread to other sites and survival rate for two years.REC name
London - Surrey Borders Research Ethics Committee
REC reference
22/PR/0299
Date of REC Opinion
28 Apr 2022
REC opinion
Favourable Opinion