Peri-operative NLR during COVID-19 pandemic [COVID-19]
Research type
Research Study
Full title
Peri-Operative Neutrophil:Lymphocyte Ratio (NLR) as a Predictor of Outcomes Following Emergency General Surgery During the COVID-19 Pandemic
IRAS ID
285260
Contact name
Nader Habib Bedwani
Contact email
Sponsor organisation
BHRUT
Duration of Study in the UK
0 years, 1 months, 5 days
Research summary
NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. We sought to investigate if a similar correlation can be identified in emergency general surgical patients and if the presence of suspected or confirmed COVID-19 may impact on this.\n\nWe therefore plan to perform a restrospective review of patients having emergency general surgery at a single NHS site during COVID-19 pandemic. Assessment of outcomes and Neutrophil:lymphocyte ratio as a predictor of outcomes will be completed. Outcomes will be completed in line with the recent COVIDSurg study criteria (3). The primary outcome is 30-day mortality. Secondary outcomes are 7-day mortality, re-operation, length of stay, post-operative respiratory failure, post-operative ARDS, post-operative sepsis and ITU/HDU admission.\n\n1. Vulliamy P, McCluney S, Mukherjee S, et al. Postoperative Elevation of the Neutrophil: Lymphocyte Ratio Predicts Complications Following Esophageal Resection. World J Surg. 2016;40(6):1397‐1403.\n2. Cook EJ, Walsh S, Farooq N, et al. Post-operative neutrophil–lymphocyte ratio predicts complications following colorectal surgery. Int J Surg. 2007;5(1):27-30.\n3 Nganwa A. CovidSurg Cohort Study. Globalsurg. https://globalsurg.org/covidsurgcohortstudy/ (accessed 22 May2020).\n
REC name
N/A
REC reference
N/A