PATTERN
Research type
Research Study
Full title
Investigation of spatial and temporal tumour heterogeneity in neuroblastoma
IRAS ID
337388
Contact name
Stefano Giuliani
Contact email
Sponsor organisation
Great Ormond Street Hospital for Children
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
PATTERN is a prospective observational cohort study of children with high-risk neuroblastoma undergoing multi-regional biopsies at multiple time points. The study will include children aged <17 years diagnosed with high-risk neuroblastoma and managed at Great Ormond Street Hospital for Children. The study will start August 2024 and run for three years.
Multiregional biopsies will be taken at diagnosis from a priori selected regions of interest. These regions will be determined by the tumour MDT. These same regions of interest will be sampled at surgery. If the disease relapses, the tumour will be sampled again (either via multiregional biopsy or surgery). Serial comparative analysis of these matched samples will provide a prospective picture of the tumour's evolution.
The study aims to: 1) describe the spatial and temporal tumour heterogeneity of high-risk neuroblastoma, and correlate this with clinical imaging, liquid biopsy, and disease outcome data (exploratory aim); 2) characterise known and novel targets for fluorescence-guided surgery in neuroblastoma and investigate how these targets respond to treatment; and 3) investigate and validate novel surgical technologies to improve surgical outcomes.
Outcomes from PATTERN will include the identification of new drivers of tumour progression and metastasis that may represent new targets for treatment. The identification and evaluation of fluorescence-guided surgery markers, and the validation of novel surgical technologies, will improve the outcomes of surgical resection, preventing local recurrence and minimising morbidity.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
24/EE/0182
Date of REC Opinion
30 Sep 2024
REC opinion
Further Information Favourable Opinion