Patient specific modelling in mitral valve surgery, version 1.0
Research type
Research Study
Full title
Impact of mitral valve surgery on cardiac ventricular response; feasibility evaluation of Computational flow dynamic modelling in degenerative and ischemic mitral valve disease
IRAS ID
221936
Contact name
Muhammad Saqib Hayat Qureshi
Contact email
Sponsor organisation
Nottingham University Hospital NHS Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Surgical repair or replacement of diseased mitral valve (MV) is a standard treatment undertaken in patients that develop mitral valve incompetence (Mitral Regurgitation; MR). This incompetence is often associated with reduction in native coronary myocardial blood flow i.e. Ischaemic MR) a variant that has altered mechanism requiring alternative approaches to short and long term management than mitral valve incompetence with no cardiac ischaemia (i.e Degenerative MR). Ischaemic MR often requires improving native myocardial blood flow using Coronary Artery Bypass Grafting (CABG) procedure at the time of MV surgery. In addition longterm MR affects the hemodynamics across Tricuspid valve making it incompetent (Tricuspid Regurgitation), which may require surgical correction at the time of MV surgery.
The premise of this study is to employ a novel tool for the assessment of mechanisms that underpin MR and its effect
on left and right ventricular function in the context of cardiac surgery. This tool named as Computational flow dynamic (CFD) modelling technique is superimposed on echocardiographic data which is routinely acquired during mitral valve surgery. CFD has shown excellent predictive potential in allied cardiac and non-cardiac applications. It is our hypothesis that CFD technique will provide as with novel measures that could effect surgical decision making in a patient specific method.This study is an observational study i.e. a study that will neither allocate patients to type of surgery or alter their preoperative or post-operative course. We will acquire preoperative and postoperative echocardiographic data in eligible patients and transfer this data to St Thomas's Hospital for CFD analysis. Routine 3 dimensional echocardiographic data will be analysed locally.
STUDY DURATION: upto 2 years
REC name
London - West London & GTAC Research Ethics Committee
REC reference
17/LO/0868
Date of REC Opinion
8 Jun 2017
REC opinion
Further Information Favourable Opinion