PATHOS-TRANS
Research type
Research Study
Full title
Transnational Analysis of Samples Collected During the Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer
IRAS ID
242666
Contact name
Terance Jones
Contact email
Sponsor organisation
University of Liverpool
Clinicaltrials.gov Identifier
14/WA/1118, PATHOS Clinical Trial REC; 10/H1002/53, H&N Biobank REC
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Biological samples are being collected from patients taking part in the PATHOS clinical trial. The PATHOS Clinical trial is a separately approved and sponsored trial for patients with HPV positive oropharyngeal cancer to look at the effectiveness of less intensive treatment following surgery.
Cancer Research UK have funded the collection of biological samples (blood and tissue) from patients recruited to the phase II and phase III PATHOS trial, this collection of samples is called PATHOS-T. This unique and high quality collection of samples can be analysed to investigate the oropharyngeal cancer and its response to treatment.
This protocol and application is to analyse the PATHOS-T samples with different methods and to identify biomarkers of treatment response, wide ranging ‘omics’ profiling, this protocol is called PATHOS-TRANS.
PATHOS-TRANS therefore represents an excellent opportunity to undertake a detailed evaluation of a disease where a lack of high quality, annotated tissue has previously prohibited this endeavour.REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
19/EM/0134
Date of REC Opinion
15 Apr 2019
REC opinion
Favourable Opinion